Magnesium – Latest Studies 05.2026
- alirezamohtashami
- May 5
- 1 min read
Updated: May 6
Magnesium is an essential mineral found in many foods and also used as a supplement. In the body, magnesium is involved in more than 300 enzyme systems. Enzymes are proteins that make many chemical processes in the body possible or faster. Magnesium plays a role in energy production, muscle function, nerve signaling, blood pressure regulation and blood glucose control.
Many people know magnesium mainly from sports, muscle topics or stress. In reality, it is a basic mineral for many metabolic processes. New data show:
Personalized supplementation and the gut microbiome: A randomized placebo-controlled trial published in 2025 investigated precision-based magnesium supplementation, with dosing adapted to genetic variants of the magnesium transporter TRPM7. In participants with adequate TRPM7 function, magnesium increased the abundance of health-associated gut bacteria such as Corynebacterium maltaromaticum and Faecalibacterium prausnitzii. These bacteria are discussed in connection with vitamin D synthesis and possible protective mechanisms in colorectal health.
Magnesium L-threonate and cognitive performance: A six-week double-blind study with 109 people with self-reported dissatisfied sleep compared 1.2 g Magtein® per day with placebo. Supplementation significantly improved total performance in neuropsychological tests, especially working memory and reaction time. Estimated cognitive brain age was reduced by about 7.5 years. Self-reported sleep quality and daytime functioning improved, while objective sleep parameters remained largely unchanged; resting heart rate decreased and heart rate variability increased.
Conclusion: Magnesium remains a highly interesting mineral with different effects depending on form, baseline status, and individual physiology. Personalized magnesium supplementation may positively influence the gut microbiome, while magnesium L-threonate shows potential for cognitive performance, reaction time, and subjective sleep quality.
04.05.2026
Author: Alireza Mohtashami
